SHORT BIO

Dr. Weisi Lu is an associated professor of the State Key Laboratory of Ophthalmic Center, Sun Yat-Sen University. Dr. Lu received her Bachelor and Ph.D degree from Sun Yat-sen University. She completed her training through a National joint-Ph.D program in Baylor College of Medicine, US (2011-2014) and went to Dr. Peter Carmeliet’s lab in Leuven University, Belgium as a visiting scholar in 2018. Dr. Lu mainly focuses on studying the signaling pathways such as PDGFs in physiological and pathological angiogenesis. She has published first- or corespondent author papers in journals including Sci Trans Med, Cancer Cell, Angiogenesis, Mol Asp Med, Cell Mol Life Sci, Pharmacol Res, and Stem cell research and therapy (total IF >116)

FUNDING (PRINCIPAL INVESTIGATOR)

2015-2028     China National Science Foundation grant, 490000 CNY

2024-2026     Guangdong National Science Foundation grant, 300000 CNY

2023-2025     Guangzhou Science and development Key Program, 420000 CNY

2021-2023     Guangzhou Basic Research and Application Research grant, 50000 CNY

2019-2021     Sun Yat-sen University Basic Research Foundation, 150000 CNY

2019-2022     Guangdong National Science Foundation grant, 100000 CNY

2019-2022     Guangdong National Science Foundation grant, 100000 CNY

2017-2019     China National Science Foundation grant, 200000 CNY

2016-2019     Guangdong National Science Foundation grant, 100000 CNY

Selected Publications

1. Wang S^#, Li W^#, Chen M^#, Cao Y, Lu W*, Li X*. The retinal epithelium: functions and roles in ocular diseases. Fundamental Research 2023 Nov 28

2. Lu W^#*, Xu P^#, Deng B^#, Zhang J^#, Zhan Y, Lin X, Xu X, Xia Z, Yang X, Zeng X, Huang L, Xie B, Wang C, Wang S, Kuang H, Han X, Mora A, Cao Y, Jiang Q*, Li X*. PDGFD switches on stem cell endothelial commitment. Angiogenesis 2022 Nov;25(4):517-533. IF=10.7

3. Tian Y, Zhan Y, Jiang Q, Lu W*, Li X*. Expression and function of PDGF-C in development and stem cells. Open Biol 2021 Dec;11(12):210268. IF=6.4

4. Lu W*, Xie Y, Huang B, Ma T, Wang H, Deng B, Zou S, Wang W, Tang Q, Yang Z, Li X*, Wang L, Fang L*. Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy. Science Translational Medicine. 2021 Feb 24;13(582):eabc2344. IF=17.9

5. Lu W*, Yu J, Shi F, Zhang J, Huang R, Yin S, Songyang Z*, Huang J*. The long non-coding RNA Snhg3 is essential for mouse embryonic stem cell self-renewal and pluripotency. Stem Cell Res Ther. 2019 May 31;10(1):157. IF=6.8

6. Yin X, Lin X, Ren X, Yu B, Liu L, Ye Z, Chen Q, Lee C, Lu W^#, Yu D^#, Li X^#. Novel multi-targeted inhibitors suppress ocular neovascularization by regulating unique gene sets. Pharmacol Res. 2019 May 18;146:104277. IF=7.7

7. Yu J*, Lu W*, Ge T, Huang R, Chen B, Ye M, Bai Y, Shi G, Songyang Z^#, Ma W^#, Huang J^#. Interaction between Sympk and Oct4 Promotes Mouse Embryonic Stem Cell Proliferation. Stem cells. 2019 Jun;37(6):743-753 IF=6.3

8. Li Y, Zhang F, Lu W^#, Li X^#. Neuronal Expression of Junctional Adhesion Molecule-C Is Essential for Retinal Thickness and Photoreceptor Survival. Curr Mol Med. 2018 Mar 9;17(7):497-508  IF=2.2

9. Lu W, Li X. Vascular stem/progenitor cells: functions and signaling pathways. Cell Mol Life Sci. 2018 Mar;75(5):859-869. IF=9

10. Lu W, Li X. PDGFs and their receptors in vascular stem/progenitor cells: Functions and therapeutic potential in retinal vasculopathy. Mol Aspects Med. 2018 Aug;62:22-32. IF=14.2

11. Huang D*, Lu W*, Zou S, Wang H, Jiang Y, Zhang X, Li P, Songyang Z, Wang L, Wang J, Huang J#, Fang L#. Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer . Cancer Sci. 2017 Jul;108(7):1293-1302. IF=6.7

12. Fang L*, Lu W*, Choi HH, Yeung SC, Tung JY, Hsiao CD, Fuentes-Mattei E, Menter D, Chen C, Wang L, Wang J, Lee MH. ERK2-dependent phosphorylation of CSN6 is critical in colorectal cancer development. Cancer Cell. 2015 28(2):183-97. IF=31.7

13. Lu W, Fang L, Ouyang B, Zhang X, Zhan S, Feng X, Bai Y, Han X, Kim H, He Q, Wan M, Shi FT, Feng XH, Liu D, Huang J^#, Songyang Z^#. Actl6a protects embryonic stem cells from differentiating into primitive endoderm. Stem Cells. 2015 33(6):1782-93. IF=6.3

14. Lu W, Zhang Y, Liu D, Songyang Z^#, Wan M^#. Telomere-structure, function, and regulation. Exp Cell Res. 2013 319(2):133-41. IF=4