Selected Publications

2023
Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption
Georgia Zarkada,* Xun Chen,* Xuetong Zhou, Martin Lange , Lei Zeng, Wenyu Lv , Xuan Zhang, Yunhua Li, Weibin Zhou, Keli Liu, Dongying Chen, Nicolas Ricard , James Liao , Young-Bum Kim , Rui Benedito, Lena Claesson-Welsh , Kari Alitalo , Michael Simons , Rong Ju, Xuri Li, Anne Eichmann , Feng Zhang
Circulation Research, 133:333-349, 2023
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway
Chunsik Lee#, Rongyuan Chen1#, Guangli Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse Jensen, Anil Kumar, Harald F. Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, Jong Kyong Kim, Juanhua Zhu, Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bi-Ang Kang, Masashi Narazaki, Aaron Prodeus, Luc Schoonjans, David M. Ornitz, Jean Gariepy, Guy Eelen, Mieke Dewerchin, Yunlong Yang, Jing-Song Ou, Antonio Mora, Jin Yao, Chen Zhao*, Yizhi Liu, Peter Carmeliet, Yihai Cao* & Xuri Li*
Signal Transduct Target Ther, 8(1):305, August 18, 2023
2022
Single Cell Atlas Identifies Lipid-Processing And Immunomodulatory Endothelial Cells In Healthy And Malignant Breast
Vincent Geldhof, Laura P.M.H. de Rooij, Liliana Sokol, Jacob Amersfoort, Maxim De Schepper, Katerina Rohlenova, Griet Hoste, Adriaan Vanderstichele, Anne-Marie Delsupehe, Edoardo Isnaldi, Naima Dai, Federico Taverna, Shawez Khan, Anh-Co K. Truong, Laure-Anne Teuwen, François Richard, Lucas Treps, Ann Smeets, Ines Nevelsteen, Birgit Weynand, Stefan Vinckier1, Luc Schoonjans, Joanna Kalucka, Christine Desmedt, Patrick Neven, Massimiliano Mazzone, Giuseppe Floris, Kevin Punie, Mieke Dewerchin, Guy Eelen, Hans Wildiers, Xuri Li*, Yonglun Luo* & Peter Carmeliet*
Nature Communications, 13(1):5511, 2022
PDGFD switches on stem cell endothelial commitment
Weisi Lu*†, Peipei Xu†, Boxiong Deng†, Jianing Zhang†, Ying Zhan, Xianchai Lin, Xiangzhong Xu, Zhaoxia Xia, Xiaoxi Yang, Xiaoling Zeng, Lijuan Huang, Bingbing Xie, Chenghu Wang, Shasha Wang, Haiqing Kuang, Xianjing Han, Antonio Mora, Yihai Cao, Qin Jiang*, Xuri Li*
Angiogenesis, July 20, 2022
Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis
Liying Xing, Guanqun Huang, Rongyuan Chen, Lijuan Huang, Juanxi Liu, Xiangrong Ren, Shasha Wan1, Haiqing Kuang, Anil Kumar, Jong Kyong Kim, Qin Jiang*, Xuri Li*, Chunsik Lee*
J Cell Commun Signal . 2023 Mar;17(1):151-165
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast
Vincent Geldhof, Laura P.M.H. de Rooij, Liliana Sokol, Jacob Amersfoort, Maxim De Schepper, Katerina Rohlenova, Griet Hoste, Adriaan Vanderstichele, Anne-Marie Delsupehe, Edoardo Isnaldi, Naima Dai, Federico Taverna, Shawez Khan, Anh-Co K. Truong, Laure-Anne Teuwen, François Richard, Lucas Treps, Ann Smeets, Ines Nevelsteen, Birgit Weynand, Stefan Vinckier1, Luc Schoonjans, Joanna Kalucka, Christine Desmedt, Patrick Neven, Massimiliano Mazzone, Giuseppe Floris, Kevin Punie, Mieke Dewerchin, Guy Eelen, Hans Wildiers, Xuri Li*, Yonglun Luo* & Peter Carmeliet*
Nat Commun . 2022 Sep 20;13(1):5511
GAD1 alleviates injury-induced ocular neurodegeneration by inhibiting retinal ganglion cell apoptosis
Yanping Zhu, Ya Zhang, Xiaoying Qi, Hongyu Che, Jingdan Jia, Chunhua Yang, Yuxue Xu, Xiaodong Chi, Wenguo Jiang, Yanuo Li, Jia Mi, Yunfan Yang*, Xuri Li*, Geng Tian
Exp Eye Res. 2022 Oct;223:109201
Chromatin Hubs: A biological and computational outlook
Antonio Morac*, Xiaowei Huang, Shaurya Jauhari, Qin Jiang, Xuri Li*
Computational and Structural Biotechnology Journal, 20:3796-3813, Jul 5 2022
PDGFD switches on stem cell endothelial commitment
Weisi Lu*#, Peipei Xu#, Boxiong Deng#, Jianing Zhang#, Ying Zhan, Xianchai Lin, Xiangzhong Xu, Zhaoxia Xia, Xiaoxi Yang, Xiaoling Zeng, Lijuan Huang, Bingbing Xie, Chenghu Wang, Shasha Wang, Haiqing Kuang, Xianjing Han, Antonio Mora, Yihai Cao, Qin Jiang*, Xuri Li*
Angiogenesis . 2022 Nov;25(4):517-533
Regional Downregulation of Dopamine Receptor D1 in Bilateral Dorsal Lateral Geniculate Nucleus of Monocular Form-Deprived Amblyopia Models
Dongyue Lin, Zhonghao Wang, Wei Chen, Tao Shen, Xuan Qiu, Kun Wei, Jiahui Li, Dongshen Yang, Ping Wang, Xuri Li, Jianhua Yan* and Zhongshu Tang*
Front Neurosci . 2022 Jun 8;16:861529
2021
Expression and function of PDGF-C in development and stem cells
Yi Tian, Ying Zhan, Qin Jiang*, Weisi Lu* and Xuri Li*
Open Biol . 2021 Dec;11(12):210268
Automatic cell type identification methods for single-cell RNA sequencing
Bingbing Xie, Qin Jiang*, Antonio Morac*, Xuri Li*
Computational and Structural Biotechnology Journal, Oct., 2021
Platelet-derived growth factor-D activates complement system to propagate macrophage polarization and neovascularization
Zhen Xiong#, Qianqian Wang#, Wanhong Li, Lijuan Huang, Jianing Zhang, Juanhua Zhu, Bingbing Xie, Shasha Wang, Haiqing Kuang, Xianchai Lin, Chunsik Lee, Anil Kumar*, Xuri Li*
Frontiers in Cell and Developmental Biology, 9:686886, Jun 2, 2021
The role of junctional adhesion molecule-C in regulating the inner endothelial blood-retinal barrier function in the eye
Xu Hou*, Hong-Jun Du, Jian Zhou, Dan Hu, Yu-Sheng Wang, Xuri Li*
Frontiers in Cell and Developmental Biology, 9:695657, Jun 7, 2021
Phenotypic diversity and metabolic specialization of renal endothelial cells
S. J. Dumas#, E. Meta, M#. Borri#, Y. Luo, Xuri Li*, T. J. Rabelink*, P. Carmeliet*
Nature Reviews Nephrology, 17(7):441-464, Jul 2021
Role of VEGFR2 in mediating endoplasmic reticulum stress under glucose deprivation and determining cell death, oxidative stress, and inflammatory factor expression
Bohan Xu#, Linbin Zhou#, Qishan Chen, Jianing Zhang, Lijuan Huang, Shasha Wang, Zhimin Ye, Xiangrong Ren, Yu Cai, Lasse Dahl Jensen, Weirong Chen*, Xuri Li*, Rong Ju*
Frontiers in Cell and Developmental Biology, 9:631413, Jun 18, 2021
Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy
Weisi Lu*#, Yunling Xie#, Binjie Huang#, Tenghui Ma#, Huaiming Wang, Boxion Deng, Shaomin Zou, Wencong Wang, Qin Tang, Ziqing Yang, Xuri Li*, Lei Wang, Lekun Fang*
Sci Transl Med, 13(582):eabc2344, 2021
Mitogen-inducible gene 6 inhibits angiogenesis by binding to SHC1 and suppressing its phosphorylation
Lixian Liu, Liying Xing, Rongyuan Chen, Jianing Zhang, Yuye Huang, Lijuan Huang, Bingbing Xie, Xiangrong Ren, Shasha Wang, Haiqing Kuang, Xianchai Lin, Anil Kumar, Jong Kyong Kim, Chunsik Lee*, Xuri Li*
Frontiers in Cell and Developmental Biology, 9:634242, Feb 22, 2021
2020
A systems genetics approach to revealing the Pdgfb molecular network of the retina
Li, S.#, Xu, F.#, Liu, L., Ju, R., Bergquist, J., Zheng, Q. Y., Mi, J., Lu, L., Xuri Li*, Tian, G.*
Mol Vis, 26:459-471, 2020
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis
Rohlenova K#, Goveia J#, García-Caballero M#, Subramanian A#, Kalucka J, Treps L, Falkenberg KD, de Rooij LPMH, Zheng Y, Lin L, Sokol L, Teuwen LA, Geldhof V, Taverna F, Pircher A, Conradi LC, Khan S, Stegen S, Panovska D, De Smet F, Staal FJT, Mclaughlin RJ, Vinckier S, Van Bergen T, Ectors N, De Haes P, Wang J, Bolund L, Schoonjans L, Karakach TK, Yang H, Carmeliet G, Liu Y, Thienpont B, Dewerchin M, Eelen G, Li X*, Luo Y*, Carmeliet P*
Cell Metabolism. 2020 Apr 07;31(4)
Single-Cell Transcriptome Atlas of Murine Endothelial Cells
Kalucka J#, de Rooij LPMH#, Goveia J#, Rohlenova K, Dumas SJ, Meta E, Conchinha NV, Taverna F, Teuwen LA, Veys K, García-Caballero M, Khan S, Geldhof V, Sokol L, Chen R, Treps L, Borri M, de Zeeuw P, Dubois C, Karakach TK, Falkenberg KD, Parys M, Yin X, Vinckier S, Du Y, Fenton RA, Schoonjans L, Dewerchin M, Eelen G, Thienpont B, Lin L, Bolund L, Li X*, Luo Y*, Carmeliet P*.
Cell. 2020 Feb 20;180(4):764-779.e20
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidate
Goveia J#, Rohlenova K#, Taverna F#, Treps L#, Conradi LC, Pircher A, Geldhof V, de Rooij LPMH, Kalucka J, Sokol L, García-Caballero M, Zheng Y, Qian J, Teuwen LA, Khan S, Boeckx B, Wauters E, Decaluwé H, De Leyn P, Vansteenkiste J, Weynand B, Sagaert X, Verbeken E, Wolthuis A, Topal B, Everaerts W, Bohnenberger H, Emmert A, Panovska D, De Smet F, Staal FJT, Mclaughlin RJ, Impens F, Lagani V, Vinckier S, Mazzone M, Schoonjans L, Dewerchin M, Eelen G, Karakach TK, Yang H, Wang J, Bolund L, Lin L, Thienpont B, Li X*, Lambrechts D, Luo Y*, Carmeliet P*.
Cancer Cell. 2020 Jan 13;37(1):21-36.e13
2019
Hallmarks of endothelial cell metabolism in health and disease
Xuri Li*, Xiaodong Sun, Peter Carmeliet*
Cell Metabolism, 30:414-433, 2019
Novel multi-targeted inhibitors suppress ocular neovascularization by regulating unique gene sets
Xiangke Yin, Xianchai Lin, Xiangrong Ren, Bo Yu, Lixian Liu, Zhimin Ye, Qishan Chen, Chunsik Lee, Weisi Lu, Dechao Yu, Xuri Li*
Pharmacol Res. 2019 Aug;146:104277
Novel function of VEGF-B as an antioxidant and therapeutic implications
Rongyuan Chen, Chunsik Lee, Xianchai Lin, Chen Zhao*, Xuri Li*
Pharmacological Research, 143:33-39, 2019
EndoDB: a database of endothelial cell transcriptomics data
Khan, S., Taverna, F., Rohlenova, K., Treps, L., Geldhof, V., de Rooij, L., Sokol, L., Pircher, A., Conradi, L. C., Kalucka, J., Schoonjans, L., Eelen, G., Dewerchin, M., Karakach, T., Li, X.*, Goveia, J., Carmeliet, P.*
Nucleic Acids Res, 47(D1): D736-D744, 2019
Metabolic pathways fueling the endothelial cell drive
Xuri Li*, Anil Kumar, & Peter Carmeliet*
Annual Reviews of Physiology, 81:483-503, 2019
2018
VEGFR2 and VEGF-C Suppresses the Epithelial-Mesenchymal Transition via YAP in Retinal Pigment Epithelial Cells
Yuxiang Du, Qishan Chen, Lijuan Huang, Xiangke Yin, Linbin Zhou, Xuri Li*, Rong Ju*
Curr Mol Med,18(5):273-286, 2018
VEGF-B is a potent antioxidant
Pachiappan Arjunan#, Xianchai Lin#, Zhongshu Tang, Yuxiang Du, Anil Kumar, Lixian Liu, Xiangke Yin, Lijuan Huang, Wei Chen, Qishan Chen, Zhimin Ye, Linbin Zhou, Kai Xu, Xue Chen, Haitao Zeng, Weisi Lu, Yihai Cao, Yizhi Liu, Chen Zhao*, Xuri Li*
PNAS, 115(41): 10351-10356, 2018
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis
Guy Eelen*, Charlotte Dubois, Anna Rita Cantelmo, Jermaine Goveia, Ulrike Brüning, Michael DeRan, Gopala Jarugumilli, Jos van Rijsse, Giorgio Saladino, Federico Comitani, Annalisa Zecchin1, Susana Rocha, Rongyuan Chen, Hongling Huang, Saar Vandekeere, Joanna Kalucka, Christian Lange, Francisco Morales-Rodriguez, Bert Cruys, Lucas Treps, Leanne Ramer, Stefan Vinckier, Katleen Brepoels, Sabine Wyns, Joris Souffreau, Luc Schoonjans, Wouter H. Lamers, Yi Wu, Jurgen Haustraete, Johan Hofkens, Sandra Liekens, Richard Cubbon, Bart Ghesquière, Mieke Dewerchin, Francesco L. Gervasio, Xuri Li*, Jaap D. van Buu, Xu Wu & Peter Carmeliet*
Nature, 561(7721):63-69, 2018
Quiescent Endothelial Cells Upregulate Fatty Acid beta-Oxidation for Vasculoprotection via Redox Homeostasis
Kalucka, J., Bierhansl, L., Conchinha, N. V., Missiaen, R., Elia, I., Bruning, U., Scheinok, S., Treps, L., Cantelmo, A. R., Dubois, C., de Zeeuw, P., Goveia, J., Zecchin, A., Taverna, F., Morales-Rodriguez, F., Brajic, A., Conradi, L. C., Schoors, S., Harjes, U., Vriens, K., Pilz, G. A., Chen, R., Cubbon, R., Thienpont, B., Cruys, B., Wong, B. W., Ghesquiere, B., Dewerchin, M., De Bock, K., Sagaert, X., Jessberger, S., Jones, E. A. V., Gallez, B., Lambrechts, D., Mazzone, M., Eelen, G., Li, X.*, Fendt, S. M., Carmeliet, P.*
Cell Metabolism, 28(6):881-894, 2018
Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
Bruning, U., Morales-Rodriguez, F., Kalucka, J.Goveia, J., Taverna, F., Queiroz, K. C. S., Dubois, C., Cantelmo, A. R., Chen, R., Loroch, S., Timmerman, E., Caixeta, V.Bloch, K., Conradi, L. C., Treps, L., Staes, A., Gevaert, K., Tee, A., Dewerchin, M., , Semenkovich, C. F., Impens, F., Schilling, B., Verdin, E., Swinnen, J. V., Meier, J. L., Kulkarni, R. A., Sickmann, A., Ghesquiere, B., Schoonjans, L., Li, X.*, Mazzone, M., Carmeliet, P.*
Cell Metabolism, 28(6):866-880, 2018
Serine synthesis via PHGDH is essential for heme production in endothelial cells
S. Vandekeere, C. Dubois, J. Kalucka, M. R. Sullivan, M. Gar-cía-Caballero, J. Goveia, R. Chen, F. F. Diehl, Libat Bar-Lev, J. Souffreau, A. Pircher, S. Kumar, S. Vinckier, Y. Hirabayashi, S-g. Furuya, L. Schoonjans, G. Eelen, B. Ghesquière, E. Keshet, X. Li*, M. G. V. Heiden, M. Dewerchin*, & P. Carmeliet*
Cell Metabolism, 28(4):573-587, 2018
RAISEing VEGF-D's importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients
Carmeliet P, Li X, Treps L, Conradi LC, Loges S.
Ann Oncol. 2018 Mar 1;29(3):527-529
Targeting angiogenic metabolism in disease.
Li X, Carmeliet P
Science. 2018 Mar 23;359(6382):1335-1336
2017
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M, Zhang Y, Yang Y, Sonmez C, Zheng W, Huang G, Seki T, Iwamoto H, Ding B, Yin L, Foukakis T, Hatschek T, Li X, Hosaka K, Li J, Yu G, Wang X, Liu Y, Cao Y.
PNAS. November 7, 2017. 114 (45) E9635-E9644
Platelet-derived growth factor-C and -D in the cardiovascular system and diseases
Chunsik Lee, Xuri Li
Mol Aspects Med. 2018 Aug;62:12-21. Epub 2017 Oct 13.
PDGF-C and PDGF-D in ocular diseases
Anil Kumar, Xuri Li
Mol Aspects Med. 2018 Aug;62:33-43. Epub 2017 Oct 27.
Vascular stem/progenitor cells: functions and signaling pathways
Weisi Lu, Xuri Li
Cell Mol Life Sci. 2018 Mar;75(5):859-869. Epub 2017 Sep 27.
Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK
Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, Yin X, Ren X, Huang L, Ye Z, Chen W, Zhang F, Mi J, Gao Z, Wang S, Chen Q, Xing L, Wang B, Cao Y, Sessa WC, Ju R, Liu Y, Li X.
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10737-10742
2016
VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis
Huang D, Zhao C, Ju R, Kumar A, Tian G, Huang L, Zheng, Li X, Liu L, Wang S, Ren X, Ye Z, Chen W, Xing L, Chen Q, Gao Z, Mi J, Tang Z, Wang B, Zhang S*, Lee C*, Li X*.
Sci Rep. 2016 May 18;6:26059.
PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently
Zheng L#, Zhao C#, Du Y, Lin X, Jiang Y, Lee C, Tian G, Mi J, Li X, Chen Q, Ye Z, Huang L, Wang S, Ren X, Xing L, Chen W, Huang D, Gao Z, Zhang S, Lu W, Tang Z, Wang B*, Ju R*, Li X*.
Oncotarget. 2016 Nov 22;7(47):77902-77915.
Placental growth factor and its potential role in diabetic retinopathy and other ocular neovascular diseases
Nguyen QD, De Falco S, Behar-Cohen F, Lam WC, Li X, Reichhart N, Ricci F, Pluim J, Li WW.
Acta Ophthalmol. 2018 Feb;96(1):e1-e9. Epub 2016 Nov 22. Review.
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
Seki T, Hosaka K, Lim S, Fischer C, Honek J, Yang Y, Andersson P, Nakamura M, Näslund E, Ylä-Herttuala S, Sun M, Iwamoto H, Li X, Liu Y, Samani NJ, Cao Y.
Nat Commun. 2016 Aug 5;7:12152.
Lens regeneration using endogenous stem cells with gain of visual function
Lin H#, Ouyang H#, Zhu J#, Huang S#, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y.
Nature. 2016 Mar 17;531(7594):323-8.
2015
Platelets induce apoptosis via membrane-bound FasL
Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O'Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF.
Blood. 2015 Sep 17;126(12):1483-93.
VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish
Jensen LD, Nakamura M, Bräutigam L, Li X, Liu Y, Samani NJ, Cao Y.
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E5944-53.
2014
Oigodendrocyte Progenitor Cells Promote Neovascularization in Glioma by Disrupting the Blood–Brain Barrier
Huang Y, Hoffman C, Rajappa P, Kim JH, Hu W, Huse J, Tang Z, Li X, Weksler B, Bromberg J, Lyden DC, Greenfield JP.
Cancer Res. 2014 Feb 15;74(4):1011-21.
Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration
He C, Zhao C, Kumar A, Lee C, Chen M, Huang L, Wang J, Ren X, Jiang Y, Chen W, Wang B, Gao Z, Zhong Z, Huang Z, Zhang F, Huang B, Ding H, Ju R, Tang Z, Liu Y, Cao Y, Li X, Liu X.
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14806-11.
2013
Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodeling and metastasis
Hosaka K, Yang Y, Seki T, Nakamura M, Andersson P, Rouhi P, Yang X, Jensen L, Lim S, Feng N, Xue Y, Li X, Larsson O, Ohhashi T, Cao Y.
Nat Commun. 2013;4:2129.
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Dong M, Yang X, Lim S, Cao Z, Honek J, Lu H, Zhang C, Seki T, Hosaka K, Wahlberg E, Yang J, Zhang L, Länne T, Sun B, Li X, Liu Y, Zhang Y, Cao Y.
Cell Metab. 2013 Jul 2;18(1):118-29.
PDGF-C: a new performer in the neurovascular interplay
Lee C, Zhang F, Tang Z, Liu Y, Li X.
Trends Mol Med. 2013 Aug;19(8):474-86.
2012
Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Langer HF#, Choi EY#, Zhou H, Schleicher R, Chung KJ, Tang Z, Göbel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T.
Circ Res. 2012 Apr 27;110(9):1202-10.
Complicated life, complicated VEGF-B
Li X, Kumar A, Zhang F, Lee C, Tang Z.
Trends Mol Med. 2012 Feb;18(2):119-27.
Proliferative and Survival Effects of PUMA Promote Angiogenesis
Zhang F, Li Y, Tang Z, Kumar A, Lee C, Zhang L, Zhu C, Klotzsche-von Ameln A, Wang B, Gao Z, Zhang S, Langer HF, Hou X, Jensen L, Ma W, Wong W, Chavakis T, Liu Y, Cao Y, Li X.
Cell Rep. 2012 Nov 29;2(5):1272-85.
2010
Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis
Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G.
Blood. 2010 Oct 21;116(16):3099-107.
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis
Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, DeAngelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD*, Chavakis T*.
Blood. 2010 Nov 25;116(22):4395-403.
*J.D.L. and T.C. contributed equally to this work
Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras
Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind JS.
Mol Cell Biol. 2010 Jun;30(12):3086-98.
VEGF-B: a thing of beauty
Xuri Li
Cell Res. 2010 Jul;20(7):741-4.
Platelet-derived Growth Factor-DD Targeting Arrests Pathological Angiogenesis by Modulating Glycogen Synthase Kinase-3beta Phosphorylation
Kumar A, Hou X, Lee C, Li Y, Maminishkis A, Tang Z, Zhang F, Langer HF, Arjunan P, Dong L, Wu Z, Zhu LY, Wang L, Min W, Colosi P, Chavakis T, Li X.
J Biol Chem. 2010 May 14;285(20):15500-10.
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets
Hou X, Kumar A, Lee C, Wang B, Arjunan P, Dong L, Maminishkis A, Tang Z, Li Y, Zhang F, Zhang SZ, Wardega P, Chakrabarty S, Liu B, Wu Z, Colosi P, Fariss RN, Lennartsson J, Nussenblatt R, Gutkind JS, Cao Y, Li X.
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12216-21
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3 phosphorylation
Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X.
J Exp Med. 2010 Apr 12;207(4):867-80.
2009
A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.
Gavard J, Hou X, Qu Y, Masedunskas A, Martin D, Weigert R, Li X, Gutkind JS.
Mol Cell Biol. 2009 May;29(9):2469-80.
Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts
Anderberg C, Li H, Fredriksson L, Andrae J, Betsholtz C, Li X, Eriksson U, Pietras K.
Cancer Res. 2009 Jan 1;69(1):369-78.
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X.
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6152-7.
2008
Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium
Li X*, Tjwa M*, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L.
Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1614-20.
*X.L. and M.T. contributed equally to this study.
VEGF-B inhibits apoptosis via VEGFR-1– mediated suppression of the expression of BH3-only protein genes in mice and rats
Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X.
J Clin Invest. 2008 Mar;118(3):913-23.
2005
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
Li X*, Tjwa M*, Moons L, Fons P, Noel A, Ny A, Zhou JM, Lennartsson J, Li H, Luttun A, Pontén A, Devy L, Bouché A, Oh H, Manderveld A, Blacher S, Communi D, Savi P, Bono F, Dewerchin M, Foidart JM, Autiero M, Herbert JM, Collen D, Heldin CH, Eriksson U, Carmeliet P.
J Clin Invest. 2005 Jan;115(1):118-27.
*X.L. and M.T. contributed equally to this study.
2003
PDGF-D is a potent transforming and angiogenic growth factor
Li H, Fredriksson L, Li X, Eriksson U.
Oncogene. 2003 Mar 13;22(10):1501-10.
Transgenic Overexpression of Platelet-Derived Growth Factor-C in the Mouse Heart Induces Cardiac Fibrosis, Hypertrophy, and Dilated Cardiomyopathy
Pontén A, Li X, Thorén P, Aase K, Sjöblom T, Ostman A, Eriksson U.
Am J Pathol. 2003 Aug;163(2):673-82.
Novel PDGF family members: PDGF-C and PDGF-D
Li X, Eriksson U.
Cytokine Growth Factor Rev. 2003 Apr;14(2):91-8. Review.
2002
Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors.
Cao R, Bråkenhielm E, Li X, Pietras K, Widenfalk J, Ostman A, Eriksson U, Cao Y.
FASEB J. 2002 Oct;16(12):1575-83.
2001
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect.
Aase K, von Euler G, Li X, Pontén A, Thorén P, Cao R, Cao Y, Olofsson B, Gebre-Medhin S, Pekny M, Alitalo K, Betsholtz C, Eriksson U.
Circulation. 2001 Jul 17;104(3):358-64.
Isoform-specific expression of VEGF-B in normal tissues and tumors.
Li X, Aase K, Li H, von Euler G, Eriksson U.
Growth Factors. 2001;19(1):49-59.
Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes.
Uutela M, Laurén J, Bergsten E, Li X, Horelli-Kuitunen N, Eriksson U, Alitalo K.
Circulation. 2001 May 8;103(18):2242-7.
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Bergsten E*, Uutela M*, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U.
Nat Cell Biol. 2001 May;3(5):512-6.
*These authors contributed equally to this work.
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.
Hellström M, Gerhardt H, Kalén M, Li X, Eriksson U, Wolburg H, Betsholtz C.
J Cell Biol. 2001 Apr 30;153(3):543-53.
Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.
Li X, Eriksson U.
Int J Biochem Cell Biol. 2001 Apr;33(4):421-6.
2000
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Li X, Pontén A, Aase K, Karlsson L, Abramsson A, Uutela M, Bäckström G, Hellström M, Boström H, Li H, Soriano P, Betsholtz C, Heldin CH, Alitalo K, Ostman A, Eriksson U.
Nat Cell Biol. 2000 May;2(5):302-9.