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Xuri Li

Scientific Director, PhD

Email

lixr6@mail.sysu.edu.cn

Short Bio

Dr. Xuri Li is a Professor and the Scientific Director of the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Dr. Li graduated from Shanghai Medical University, obtained her Ph.D. from Karolinska Institute in Stockholm, Sweden, and received her postdoctoral training at the Karolinska Institute and the Vesalius Research Center in Leuven University, Belgium. During 2005-2012, Dr. Li served as a Principal Investigator at the National Institutes of Health, National Eye Institute in USA. Dr. Li has published 125 scientific publications (total IF ≥ 1579) and is a referee of 32 international journals. Dr. Li is an inventor of numerous international patents and is the founder of the Asia Pacific Vascular Biology Organization (APVBO).

Major Research Interests

Our team strives to understand the processes of angiogenesis, vasculogenesis and neurogenesis in the eye in development, normal physiology and various pathologies. We hope to use the gained knowledge to explore better therapies for human diseases. Specifically, we characterize the functional properties of important angiogenic and antiangiogenic molecules using animal models, cultured cells and molecular approaches. We also utilize the developing mouse eye as a model to explore the fundamental mechanisms of angiogenesis, vasculargenesis and neurogenesis. Furthermore, we try to reveal the basic cellular and molecular mechanisms underlying our findings.


NIH Intramural Funding as a Principal Investigator

2006                                                              US $1,770,000

2007               1Z01EY000447-01                US $1,774,036

2008               1Z01EY000447-02                US $1,523,283

2009               1ZIAEY000447-03                US $1,347,483

2010               1ZIAEY000447-04                US $1,342,304

2011               1ZIAEY000447-05                US $1,409,461

2012               1ZIAEY000447-06                US $1,047,086

 

FUNDING IN  CHINA AS  A PRINCIPAL INVESTIGATOR


2013-2017                   1000-Plan Expert, Leading Expert of the Sun Yat-Sen University, Principal Investigator, 12000000 CNY

2014-2018                   NSFC National Key Program, Principal Investigator, 2900000 CNY

2014-2018                   Guangdong Province Leading Expert Program, Principal Investigator, 5000000 CNY

2016-2017                   NSFC China-Sweden International Collaboration Program, Principal Investigator, 240000 CNY

2017-2020                   NSFC grant, Principal Investigator, 540000 CNY

2018-2021                   Guangzhou Science and Development Key Program, Principal Investigator, 2000000 CNY

2019-2022                   Boehringer-Ingelheim innovation research grant, 3628800 CNY

2022-2023                   NSFC, National Key Program for Senior Foreign Scientist, Principal Investigator, 1600000 RMB

2023-2027                   NSFC, National Key Program for International Collaboration, Principal Investigator, 2520000 RMB

2024-2026                   Ministry of Science and Technology of China, Stem cell and gene therapy for AMD, 10000000 RMB



REVIEWED SCIENTIFIC MANUSCRIPTS FOR:


  1. Nature Communications

  2. Nature Metabolism

  3. Nature Protocols

  4. Blood

  5. Circulation Research

  6. Journal of Experimental Medicine

  7. Clinical Cancer Research

  8. Proceedings of the National Academy of Sciences USA

  9. Developmental Cell

  10. Genome Biology

  11. Clinical and Translational Medicine

  12. Molecular Therapy

  13. Cell Reports

  14. Biomaterials

  15. The FASEB Journal

  16. Cancer Letters

  17. Gene Therapy

  18. Oncogene

  19. The Journal of Pathology

  20. The American Journal of Pathology

  21. Science Advances

  22. International Journal of Biological Macromolecules

  23. Aging

  24. Biomolecules

  25. iScience

  26. PLoS ONE

  27. Pigment Cell & Melanoma Research

  28. Experimental Eye Research

  29. Investigative Ophthalmology and Visual Science

  30. British Journal of Ophthalmology

  31. Journal of Visualized Experiments

  32. Journal of Geriatric Cardiology



REVIEWED RESEARCH GRANT FOR:


  • Intercellular Interactions Study Section, Center for Scientific Review, NIH, USA

  • Atherosclerosis and Inflammation in the Cardiovascular Systems Study Section, Center for Scientific Review, NIH, USA

  • The Agency for Science, Technology and Research’s (A*STAR), Biomedical Research Council (BMRC), Singapore

  • Ministry of Research and Innovation, Government of Ontario, Canada

  • Medical Research Council, Research Councils UK

  • American Institute of Biological Sciences (AIBS), USA

  • The National Natural Science Foundation of China (NSFC)




Selected Publications

  1. Ekstrom T.J., Cui H., Xuri Li, Ohlsson R., Promoter-specific IGF2 imprinting status and its plasticity during human liver development, Development, 121(2):309-316, 1995, PubMed   

  2. Xuri Li, Adam G., Cui H., Sandstedtedt B., Ohlsson R., Ekstrom T.J. Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting, Oncogene, 1(2):221-229, 1995, PubMed   

  3. Xuri Li, Nong Z., Ekström C., Larsson E., Nordlinder H., Hofmann W. J, Trautwein C., Odenthal M., Dienes H.P., Ekstrom T. J. and Schirmacher P. Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma, Cancer Res, 57(10):2048-2054, 1997, PubMed

  4. Xuri Li, Ponten A., Aase K., Linda K., Abramsson A., Uutela M., Backman G., Hellstrom M., Bostrom H., Li H., Betsholtz C., Heldin C. H., Alitalo K., Ostman A. & Eriksson U. PDGF-C is a new protease-activated ligand for the PDGF-a receptor, Nat Cell Biol, 2(5):302-309, 2000 PubMed

    (Featured News & Views: A new member of an old family, Nat Cell Biol, 2(5): E78-79, 2000 PubMed)

  5. Bergsten, E., Uutela, M., Xuri Li, Pietras, K., Ostman, A., Heldin, C. H., Alitalo, K., Eriksson, U. PDGF-D is a specific, protease-activated ligand for the PDGF beta-Receptor, Nat Cell Biol, 3(5):515-516, 2001, PubMed

  6. Hellstrom, M., Gerhardt, H., Kalen, M., Xuri Li, Eriksson, U., Wolburg, H., Betsholtz, C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis, J Cell Biol, 153(3):543-554, 2001, PubMed

  7. Uutela, M., Lauren, J., Bergsten, E., Xuri Li, Horelli-Kuitunen, N., Eriksson, U., Alitalo, K., Chromosomal location, exon structure, and vascular expression patterns of the human PDGF-C and PDGF-C genes, Circulation, 103(18):2242-2247, 2001, PubMed

  8. Aase, K., Von Euler, G., Xuri Li, Ponten, A., Thoren, P., Cao, Y., Olofsson, B., Gebre-Medhin, S., Pekny, M., Alitalo, K., Betsholtz C., Eriksson, U. VEGF-B deficient mice display an atrial conduction defect, Circulation, 104(3):358-364, 2001, PubMed

  9. Eitner F., Ostendorf T., Van Roeyen C., Kitahara M., Xuri Li, Aase K., Groene H-J., Eriksson U., Floege J. Expression of a Novel PDGF Isoform, PDGF-C, in Normal and Diseased Rat Kidney, J Am Soc Nephrol, 13(4):910-917, 2002, PubMed

  10. Cao, R., Brakenhielm, E., Xuri Li, Pietras K., Widenfalk J., Ostman A., Eriksson, U., Cao, Y. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors, FASEB J, 16(12):1575-1583, 2002, PubMed

  11.  Li, H., Karlsson L., Xuri Li, Eriksson, U. PDGF-D is a potent transforming and angiogenic factor, Oncogene, 22(10):1501-1510, 2003, PubMed

  12. Ponten A., Xuri Li, Aase K., Thoren P., Sjoblom T., Ostman A. and Eriksson U., Overexpression of PDGF-C in mouse heart induces cardiac fibrosis, hypertrophy and dilated cardiomyopathy, Am J Pathol, 163(2):673-682, 2003, PubMed

  13. Fredriksson, L., Li, H., Fieber, C., Xuri Li and Eriksson U., Tissue plasminogen activator is a potent activator of PDGF-CC, EMBO, 23(19):3793-3802, 2004, PubMed

  14. Xuri Li, Tjwa, M., Moons, L., Fons, P., Noel, A., Ny, A., Zhou, J. M., Lennartsson, J., Li, H., Luttun, A., Ponten, A., Devy, L., Bouche, A., Oh, H., Manderveld, A., Blacher, S., Communi, D., Savi, P., Bono, F., Dewerchin, M., Foidart, J. M., Autiero, M., Herbert, J. M., Collen, D., Heldin, C. H., Eriksson, U., Carmeliet, P., Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors, J Clin Invest, 115(1):118-127, 2005, PubMed

    JCI Article In The News: PDGF-CC, the best thing ever since sliced bread? J Clin Invest, 115(1), 2005 website

    Featured News: Platelet-derived growth factor CC--a clinically useful angiogenic factor at last?, N Engl J Med, 352(17): 1815-1816, 2005 website

  15. Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang, C., Hua, J., Matsuo, O., Fong, G. H., Ding, H., Cao, Y., Becker, K. G., Nash, A., Heldin, C. H., Xuri Li*, VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats, J Clin Invest, 118(3):913–923, 2008, PubMed

  16. Xuri Li, Tjwa, M., Van Hove, I., Enholm, B., Neven, E., Paavonen, K., Jeltsch, M., Diez Juan, T., Sievers, R. E., Chorianopoulos, E., Wada, H., Vanwildemeersch, M., Noel, A., Foidart, J. M., Springer, M. L., von Degenfeld, G., Dewerchin, M., Blau, H. M., Alitalo, K., Eriksson, U., Carmeliet, P., Moons, L., Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium, Arterioscler Thromb Vasc Biol, 28(9):1614-1620, 29, 2008, PubMed

  17. Anderberg, C., Li, H., Fredriksson, L., Andrae, J., Betsholtz, C., Xuri Li, Eriksson, U., Pietras, K., Paracrine signaling by PDGF-CC promotes tumor growth by recruitment of cancer-associated fibroblasts, Cancer Res, 69(1):369-378, 2009, PubMed

  18. Gavard, J., Hou, X., Qu, Y., Masedunskas, A., Weigert, R., Xuri Li, Gutkind, JS., A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability, Mol Cell Biol, 29(9):2469-2480, 2009, PubMed

  19. Zhang, F., Tang, Z., Hou, X., Lennartsson, J., Li, Y., Koch, A. W., Scotney, P., Lee, C., Arjunan, P., Dong, L., Kumar, A., Rissanen, T. T., Wang, B., Nagai, N., Fons, P., Fariss, R., Zhang, Y., Wawrousek, E., Tansey, G., Raber, J., Fong, G. H., Ding, H., Greenberg, D. A., Becker, K. G., Herbert, J. M., Nash, A., Yla-Herttuala, S., Watts, R. J., Xuri Li*, VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis, Proc Natl Acad Sci USA, 106(15):6152-6157, 2009, PubMed

  20. Tang, Z., Arjunan, P., Lee, C., Li, Y., Kumar, A., Hou, X., Wang, B., Wardega, P., Zhang, F., Dong, L., Zhang, Y., Zhang, S. Z., Ding, H., Fariss, R. N., Becker, K. G., Lennartsson, J., Nagai, N., Cao, Y., Xuri Li*, Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation, J Exp Med, 207(4):867-880, 2010, PubMed

  21. Kumar, A., Hou, X., Lee, C., Li, Y., Maminishkis, A., Tang, Z., Zhang, F., Langer, H. F., Arjunan, P., Dong, L., Wu, Z., Zhu, L. Y., Wang, L., Min, W., Colosi, P., Chavakis, T., Xuri Li*, PDGF-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase 3 beta (GSK3{beta}) phosphorylation, J Biol Chem, 285(20):15500-15510, 2010, PubMed

    Cover image for J Biol Chem, 285(20), 2010 website

  22. Sakurai, A., Gavard, J., Annas-Linhares, Y., Basile, J. R., Amornphimoltham, P., Palmby, T. R., Yagi, H., Zhang, F., Randazzo, P. A., Xuri Li, Weigert, R., Gutkind, J. S., Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras, Mol Cell Biol, 30(12):3086-98, 2010, PubMed

  23. Hou, X., Kumar, A., Lee, C., Wang, B., Arjunan, P., Dong, L., Maminishkis, A., Tang, T., Li, Y., Zhang, F., Zhang, S-Z., Wardega, P., Chakrabarty, S., Liu, B., Wu, Z., Colosi, P., Fariss, R. N., Lennartsson, J., Nussenblatt, R., Gutkind, J. S., Cao, Y., Xuri Li*, PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets, Proc Natl Acad Sci USA, 107(27):12216-12221, 2010, PubMed

  24. Narazaki, M., Segarra, M., Hou, X., Tanaka, T., Xuri Li, Tosato, G., Oligo-guanosinenucleotide induces Neuropilin-1 internalization in endothelial cells and inhibits angiogenesis, Blood, 116(16):3099-3107, 2010, PubMed

  25. Langer, H. L., Chung, K-J., Orlova, V. V., Choi, E. Y., Kaul, S., Kruhlak, M. J., Alatsatianos, M., DeAngelis, R. A., Roche, P. A., Magotti, P., Xuri Li, Economopoulou, M., Rafail, S., Lambris, J. D., Chavakis, T., Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis, Blood, 116(22):4395-4403, 2010, PubMed

  26. Xuri Li*, VEGF-B: a thing of beauty, Cell Res, 20(7): 741-744, 2010, PubMed

  27. Langer, H. F., Choi, E. Y., Zhou, H., Schleicher, R., Chung, K. J., Tang, Z., Gobel, K., Bdeir, K., Chatzigeorgiou, A., Wong, C., Bhatia, S., Kruhlak, M. J., Rose, J. W., Burns, J. B., Hill, K. E., Qu, H., Zhang, Y., Lehrmann, E., Becker, K. G., Wang, Y., Simon, D. I., Nieswandt, B., Lambris, J. D., Xuri Li, Meuth, S. G., Kubes, P., Chavakis, T., Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis, 110(9):1202-1210, Circ Res, 2012, PubMed

  28. Zhang, F., Li, Y., Tang, Z., Kumar, A., Lee, C., Zhang, L., Zhu, C., Ameln, A. K., Wang, B., Gao, Z., Zhang, S., Langer, H., Hou, X., Jensen, L., Ma, W., Wong, W., Chavakis, T., Liu, Y., Cao, Y., Xuri Li*, Proliferative and survival effects of PUMA promotes angiogenesis, 2(5):1272-1285, Cell Reports, 2012, PubMed     

    Biomedical Picture of the Day: Double Agent PUMA, Website

  29. Segarra, M., Ohnuki, H., Maric, D., Salvucci, O., Hou, X., Xuri Li, and Tosato, G., Semaphorin 6A regulates angiogenesis by modulating VEGF signaling, Blood, 120(19):4104-4115, 2012, PubMed

  30. Xuri Li*, Kumar, A., Zhang, F., Lee, C., Tang, Z., Complicated life, complicated VEGF-B, Trends Mol Med, 18(2):119–127, 2012, PubMed

    Cover image for Trends in Molecular Medicine, 18(2), 2012, Website

  31. Hosaka, K., Yang, Y., Seki, T., Nakamura, M., Andersson, P., Rouhi, P., Yang, X., Jensen, L., Lim, S., Feng, N., Xue, Y., Xuri Li, Larsson, O., Ohhashi, T., Cao, Y., Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis, Nat Commun, 4:2129, 2013, PubMed

  32. Dong, M., Yang, X., Lim, S., Cao, Z., Honek, J., Lu, H., Zhang, C., Seki, T., Hosaka, K., Wahlberg, E., Yang, J., Zhang, L., Lanne, T., Sun, B., Xuri Li, Liu, Y., Zhang, Y., Cao, Y., Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent Lipolysis, Cell Metab, 18(1):118-129. 2013, PubMed

  33. Lee, C., Zhang, F., Tang, Z., Liu, Y., Xuri Li*, PDGF-C: a new performer in the neurovascular interplay, Trends Mol Med, 19(8):474-86, 2013, PubMed

  34. Huang, Y., Hoffman, C., Rajappa, P., Kim, J. H., Hu, W., Huse, J. T., Tang, Z., Xuri Li, Weksler, B., Bromberg, J., Lyden, D., Greenfield, J. P., Oligodendrocyte progenitor cells promote neovascularization in glioma by disrupting the blood-brain barrier, Cancer Res, 74(4):1011-1021, 2014, PubMed

  35. He, C., Zhao, C., Kumar, A., Lee, C., Chen, M., Huang, L., Wang, J., Ren, X., Jiang, Y., Chen, W., Wang, B., Gao, Z., Zhong, Z., Huang, Z., Zhang, F., Huang, B., Ding, H., Ju, R., Tang, Z., Liu, Y., Cao, Y., Xuri Li*., Liu, X*., Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration, Proc Natl Acad Sci U S A, 111(41):14806-11, 2014, PubMed

  36. Salvucci, O., Ohnuki, H., Maric, D., Hou, X., Xuri Li, Yoon, S. O., Segarra, M., Eberhart, C. G., Acker-Palmer, A., Tosato, G., EphrinB2 controls vessel pruning through STAT1-JNK3 signalling, Nat Commun, 6:6576, 2015, PubMed

  37.  R. I. Schleicher, F. Reichenbach, P. Kraft, A. Kumar, M. Leskan, F. Todt, K. Goebel, T. Geisler, A. Bauer, S. Wesselborg, L. O’Reilly, S. G. Meuth, K. Schulze-Osthoff, M. Gawaz, Xuri Li, C. Kleinschnitz, F. Edlich, H. Langer, Platelets induce apoptosis via membrane-bound FasL, Blood, 126(12):1483-1493, 2015, PubMed

  38. L D. Jensena, M Nakamuraa, L Bräutigamc, Xuri Li, Y Liu, N J. Samanie, and Y Cao, VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish, Proc Natl Acad Sci U S A, 12(44):E5944-53, 2015, PubMed

  39. Lin, H., Ouyang, H., Zhu, J., Huang, S., Liu, Z., Chen, S., Cao, G., Li, G., Signer, R. A., Xu, Y., Chung, C., Zhang, Y., Lin, D., Patel, S., Wu, F., Cai, H., Hou, J., Wen, C., Jafari, M., Liu, X., Luo, L., Qiu, A., Hou, R., Chen, B., Chen, J., Granet, D., Heichel, C., Shang, F., Xuri Li, Krawczyk, M., Skowronska-Krawczyk, D., Wang, Y., Shi, W., Chen, D., Zhong, Z., Zhong, S., Zhang, L., Morrison, S. J., Maas, R. L., Zhang, K., Liu, Y., Lens regeneration using endogenous stem cells with gain of visual function, Nature, 351(7594):323-328, 2016, PubMed

  40. Seki, T., Hosaka, K., Lim, S., Fischer, C., Honek, J., Yang, Y., Andersson, P., Nakamura, M., Naslund, E., Yla-Herttuala, S., Sun, M., Iwamoto, H., Xuri Li, Liu, Y., Samani, N. J., Cao, Y., Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat, Nat Commun, 7:12152, 2016, PubMed

  41. Jiang, Y., Lin, X., Tang, Z., Lee, C., Tian, G., Du, Y., Yin, X., Ren, X., Huang, L., Ye, Z., Chen, W., Zhang, F., Mi, J., Gao, Z., Wang, S., Chen, Q., Xing, L., B. Wang, Y. Cao, W. C. Sessa, R. Ju*, Y. Liu*, Xuri Li*, Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK, Proc Natl Acad Sci U S A, 114(40): 10737-10742, 2017, PubMed

  42. Weisi Lu, Xuri Li*, Vascular stem/progenitor cells: functions and signaling pathways, Cell Mol Life Sci, 75(5):859-869, 2017, PubMed

  43. Xuri Li*, Carmeliet, P.*, Targeting angiogenic metabolism in disease, Science, 359(6382):1335-1336, 2018, PubMed

  44. Chunsik Lee, Xuri Li*, Platelet-derived growth factor-C and -D in the cardiovascular system and diseases, Molecular Aspects of Medicine, 62:12-21, 2018, PubMed

  45. Weisi Lu, Xuri Li*, PDGFs and their receptors in vascular stem/progenitor cells: Functions and therapeutic potential in retinal vasculopathy, Molecular Aspects of Medicine, 62:22-32, 2018, PubMed

  46. Anil Kumar, Xuri Li*, PDGF-C and PDGF-D in ocular diseases, Molecular Aspects of Medicine, 62:33-43, 2018, PubMed

  47. S. Vandekeere, C. Dubois, J. Kalucka, M. R. Sullivan, M. Gar-cía-Caballero, J. Goveia, R.  Chen, F. F. Diehl, Libat Bar-Lev, J. Souffreau, A. Pircher, S. Kumar, S. Vinckier, Y. Hirabayashi, S-g. Furuya, L. Schoonjans, G. Eelen, B. Ghesquière, E. Keshet, Xuri Li*, M. G. V. Heiden, M. Dewerchin*, & P. Carmeliet*, Serine synthesis via PHGDH is essential for heme production in endothelial cells, Cell Metabolism, 28(4):573-587, 2018, PubMed

  48. Bruning, U., Morales-Rodriguez, F., Kalucka, J.Goveia, J., Taverna, F., Queiroz, K. C. S., Dubois, C., Cantelmo, A. R., Chen, R., Loroch, S., Timmerman, E., Caixeta, V.Bloch, K., Conradi, L. C., Treps, L., Staes, A., Gevaert, K., Tee, A., Dewerchin, M., , Semenkovich, C. F., Impens, F., Schilling, B., Verdin, E., Swinnen, J. V., Meier, J. L., Kulkarni, R. A., Sickmann, A., Ghesquiere, B., Schoonjans, L., Xuri Li*, Mazzone, M., Carmeliet, P.*, Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation, Cell Metabolism, 28(6):866-880, 2018, PubMed

  49. Kalucka, J., Bierhansl, L., Conchinha, N. V., Missiaen, R., Elia, I., Bruning, U., Scheinok, S., Treps, L., Cantelmo, A. R., Dubois, C., de Zeeuw, P., Goveia, J., Zecchin, A., Taverna, F., Morales-Rodriguez, F., Brajic, A., Conradi, L. C., Schoors, S., Harjes, U., Vriens, K., Pilz, G. A., Chen, R., Cubbon, R., Thienpont, B., Cruys, B., Wong, B. W., Ghesquiere, B., Dewerchin, M., De Bock, K., Sagaert, X., Jessberger, S., Jones, E. A. V., Gallez, B., Lambrechts, D., Mazzone, M., Eelen, G., Xuri Li*, Fendt, S. M., Carmeliet, P.*, Quiescent Endothelial Cells Upregulate Fatty Acid beta-Oxidation for Vasculoprotection via Redox Homeostasis, Cell Metabolism, 28(6):881-894, 2018, PubMed

  50. Eelen, G., Dubois, C., Cantelmo, A. R., Goveia, J., Bruning, U., DeRan, M., Jarugumilli, G., van Rijssel, J., Saladino, G., Comitani, F., Zecchin, A., Rocha, S., Chen, R., Huang, H., Vandekeere, S., Kalucka, J., Lange, C., Morales-Rodriguez, F., Cruys, B., Treps, L., Ramer, L., Vinckier, S., Brepoels, K., Wyns, S., Souffreau, J., Schoonjans, L., Lamers, W. H., Wu, Y., Haustraete, J., Hofkens, J., Liekens, S., Cubbon, R., Ghesquiere, B., Dewerchin, M., Gervasio, F. L., Xuri Li*, van Buul, J. D., Wu, X., & Carmeliet, P.*, Role of glutamine synthetase in angiogenesis beyond glutamine synthesis, Nature, 561(7721):63-69, 2018, PubMed

  51. Arjunan, P., Lin, X., Tang, Z., Du, Y., Kumar, A., Liu, L., Yin, X., Huang, L., Chen, W., Chen, Q., Ye, Z., Wang, S., Kuang, H., Zhou, L., Xu, K., Chen, X., Zeng, H., Lu, W., Cao, Y., Liu, Y., Zhao, C.*, Xuri Li*, VEGF-B is a potent antioxidant, Proc Natl Acad Sci U S A, 115(41): 10351-10356, 2018, PubMed

  52. Metabolic pathways fueling the endothelial cell drive, Xuri Li*, Anil Kumar, & Peter Carmeliet*, Annual Reviews of Physiology, 81:483-503, 2019, PubMed

  53. EndoDB: a database of endothelial cell transcriptomics data, Khan, S., Taverna, F., Rohlenova, K., Treps, L., Geldhof, V., de Rooij, L., Sokol, L., Pircher, A., Conradi, L. C., Kalucka, J., Schoonjans, L., Eelen, G., Dewerchin, M., Karakach, T., Xuri Li*, Goveia, J., Carmeliet, P.*, Nucleic Acids Res, 47(D1): D736-D744, 2019, PubMed

  54. Hallmarks of Endothelial Cell Metabolism in Health and Disease, Cell Metabolism, Xuri Li*, Sun, X., Carmeliet, P.*, 30:414-433, 2019, PubMed

  55. An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates, Goveia, J., Rohlenova, K., Taverna, F., Treps, L., Conradi, L. C., Pircher, A., Geldhof, V., de Rooij, Lpmh, Kalucka, J., Sokol, L., Garcia-Caballero, M., Zheng, Y., Qian, J., Teuwen, L. A., Khan, S., Boeckx, B., Wauters, E., Decaluwe, H., De Leyn, P., Vansteenkiste, J., Weynand, B., Sagaert, X., Verbeken, E., Wolthuis, A., Topal, B., Everaert, W., Bohnenberger, H., Emmert, A., Panovska, D., De Smet, F., Staal, F. J. T., McLaughlin, R. J., Impens, F., Lagani, V., Vinckier, S., Mazzone, M., Schoonjans, L., Dewerchin, M., Eelen, G., Karakach, T. K., Yang, H., Wang, J., Bolund, L., Lin, L., Thienpont, B., Xuri Li*, Lambrechts, D., Luo, Y., Carmeliet, P.*, Cancer Cell, 37(1): 21-36 e13, Jan., 2020, PubMed

  56. Single-Cell Transcriptome Atlas of Murine Endothelial Cells, Kalucka, J., de Rooij, Lpmh, Goveia, J., Rohlenova, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L. A., Veys, K., Garcı´a-Caballero, M., Khan, S., Geldhof, V., Sokol, L., Chen, R., Treps, L., Borri, M., de Zeeuw, P., Dubois,C., Karakach, T. K., Falkenberg, K. D., Parys, M., Yin, X., Vinckier, S., Du, Y., Fenton, R. A., Schoonjans, L., Dewerchin, M., Eelen, G., Thienpont, B., Lin, L., Bolund, L., Xuri Li*, Luo, Y.,* & Carmeliet, P.*, Cell, 180(4): 764-779 e20, 2020, PubMed

  57. Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis, Rohlenova, K., Goveia, J., Garcia-Caballero, M., Subramanian, A., Kalucka, J., Treps, L., Falkenberg, K. D., de Rooij, Lpmh, Zheng, Y., Lin, L., Sokol, L., Teuwen, L. A., Geldhof, V., Taverna, F., Pircher, A., Conradi, L. C., Khan, S., Stegen, S., Panovska, D., De Smet, F., Staal, F. J. T., McLaughlin, R. J., Vinckier, S., Van Bergen, T., Ectors, N., De Haes, P., Wang, J., Bolund, L., Schoonjans, L., Karakach, T. K., Yang, H., Carmeliet, G., Liu, Y., Thienpont, B., Dewerchin, M., Eelen, G., Xuri Li*, Luo, Y.,* & Carmeliet, P.*, Cell Metab, 31(4): 862-877 e14, April, 2020, PubMed

  58. Eelen, G., Treps, L., Xuri Li, Carmeliet, P., Basic and Therapeutic Aspects of Angiogenesis Updated." Circ Res, 127(2): 310-329, 2020, PubMed

  59. Weisi Lu*, Yunling Xie1, Binjie Huang1, Tenghui Ma, Huaiming Wang, Boxion Deng, Shaomin Zou, Wencong Wang, Qin Tang, Ziqing Yang, Xuri Li*, Lei Wang, Lekun Fang*, Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy, Sci Transl Med, 13, eabc2344, 24 February 2021, PubMed

  60. S. J. Dumas, E. Meta, M. Borri, Y. Luo, Xuri Li*, T. J. Rabelink*, P. Carmeliet*, Phenotypic diversity and metabolic specialization of renal endothelial cells, Nature Reviews Nephrology, March 25, 2021, PubMed

  61. Weisi Lu*†, Peipei Xu†, Boxiong Deng†, Jianing Zhang†, Ying Zhan, Xianchai Lin, Xiangzhong Xu, Zhaoxia Xia, Xiaoxi Yang, Xiaoling Zeng, Lijuan Huang, Bingbing Xie, Chenghu Wang, Shasha Wang, Haiqing Kuang, Xianjing Han, Antonio Mora, Yihai Cao, Qin Jiang*, Xuri Li*, PDGFD switches on stem cell endothelial commitment, Angiogenesis, July 20, 2022

  62. Vincent Geldhof, Laura P.M.H. de Rooij, Liliana Sokol, Jacob Amersfoort, Maxim De Schepper, Katerina Rohlenova, Griet Hoste, Adriaan Vanderstichele, Anne-Marie Delsupehe, Edoardo Isnaldi, Naima Dai, Federico Taverna, Shawez Khan, Anh-Co K. Truong, Laure-Anne Teuwen, François Richard, Lucas Treps, Ann Smeets, Ines Nevelsteen, Birgit Weynand, Stefan Vinckier1, Luc Schoonjans, Joanna Kalucka, Christine Desmedt, Patrick Neven, Massimiliano Mazzone, Giuseppe Floris, Kevin Punie, Mieke Dewerchin, Guy Eelen, Hans Wildiers, Xuri Li*, Yonglun Luo* & Peter Carmeliet*, Single Cell Atlas Identifies Lipid-Processing And Immunomodulatory Endothelial Cells In Healthy And Malignant Breast, Nature Communications, 13(1):5511, 2022

  63. VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway, Chunsik Lee#, Rongyuan Chen#, Guangli Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse Jensen, Anil Kumar, Harald F. Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, Jong Kyong Kim, Juanhua Zhu,  Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bi-Ang Kang, Masashi Narazaki, Aaron Prodeus, Luc Schoonjans, David M. Ornitz, Jean Gariepy, Guy Eelen, Mieke Dewerchin, Yunlong Yang, Jing-Song Ou, Antonio Mora, Jin Yao, Chen Zhao*, Yizhi Liu, Peter Carmeliet, Yihai Cao* & Xuri Li*, Signal Transduct Target Ther, 8(1):305, August 18, 2023

  64. Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption, Georgia Zarkada,* Xun Chen,* Xuetong Zhou, Martin Lange , Lei Zeng, Wenyu Lv , Xuan Zhang, Yunhua Li, Weibin Zhou, Keli Liu, Dongying Chen, Nicolas Ricard , James Liao , Young-Bum Kim , Rui Benedito, Lena Claesson-Welsh , Kari Alitalo , Michael Simons , Rong Ju, Xuri Li, Anne Eichmann , Feng Zhang, Circulation Research, 133:333-349, 2023

Book Chapters

  1. Eriksson, U., Li, X. Chapter: Vascular Endothelial Growth Factor B (VEGF-B),Encyclopedia of Hormones, edited by Henry, HL & Norman, AW, Elsevier Science, Academic press, 2003

  2. Li, X.*, Kumar, A., Lee, C., Tang, Z., Li, Y., Arjunan, P., Hou, X., Zhang, F., Can VEGF-B be used to treat neurodegenerative diseases? Neurodegenerative Diseases - Book 1, ISBN 979-953-307-041-3, InTech, Open Access Publisher, 2011

  3. Ju, R., Lee, C., Lu, W., Li, X*., Fibroblast Growth Factors: Biology and Clinical Application, Growth Factors in the Eye, ISBN: 978-981-3143-36-4, World Scientific, 2017

 

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